UHRF1

UHRF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FAZ, 2L3R, 2LGG, 2LGK, 2LGL, 2PB7, 3ASK, 3ASL, 3BI7, 3CLZ, 3DB3, 3DB4, 3DWH, 3FL2, 3SHB, 3SOU, 3SOW, 3SOX, 3T6R, 3ZVY, 3ZVZ, 4GY5, 4QQD, 5C6D, 5IAY
Identifiers
Aliases	UHRF1, ICBP90, Np95, RNF106, hNP95, hhuNp95, TDRD22, ubiquitin like with PHD and ring finger domains 1
External IDs	OMIM: 607990; MGI: 1338889; HomoloGene: 7866; GeneCards: UHRF1; OMA:UHRF1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	4,962,154 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,630,486 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; thymus; ; ventricular zone; ; ganglionic eminence; ; buccal mucosa cell; ; trabecular bone; ; mucosa of ileum; ; bone marrow; ; stromal cell of endometrium;
	Top expressed in
	secondary oocyte; ; primary oocyte; ; maxillary prominence; ; tail of embryo; ; zygote; ; mandibular prominence; ; abdominal wall; ; dermis; ; epiblast; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; ubiquitin protein ligase activity; hemi-methylated DNA-binding; DNA-binding transcription factor activity; methyl-CpG binding; cis-regulatory region sequence-specific DNA binding; metal ion binding; ubiquitin-protein transferase activity; methylated histone binding; protein binding; identical protein binding; transferase activity; zinc ion binding; histone binding;
Cellular component	euchromatin; nuclear matrix; replication fork; heterochromatin; nucleus;
Biological process	histone monoubiquitination; positive regulation of protein metabolic process; regulation of transcription, DNA-templated; maintenance of DNA methylation; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of DNA methylation-dependent heterochromatin assembly; cellular response to DNA damage stimulus; protein ubiquitination; cell cycle; cell population proliferation; histone ubiquitination; DNA repair; positive regulation of transcription by RNA polymerase II; protein autoubiquitination; chromatin organization; ubiquitin-dependent protein catabolic process; regulation of epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	29128
	18140
	ENSG00000276043
	ENSMUSG00000001228
	Q96T88
	Q8VDF2
	NM_001048201; NM_001290050; NM_001290051; NM_001290052; NM_013282
	NM_001111078; NM_001111079; NM_001111080; NM_010931
	NP_001041666; NP_001276979; NP_001276980; NP_001276981; NP_037414
	NP_001104548; NP_001104549; NP_001104550; NP_035061
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene. It acts as an epigenetic regulator that links DNA methylation to histone modifications and has been implicated in several key cellular processes, including DNA replication, the maintenance of DNA methylation, and the repair of DNA damage. Because it coordinates several layers of epigenetic regulation, it is considered an integrative epigenetic hub. The gene is overexpressed in numerous cancer types, making it a potential therapeutic target. Several transcript variants encoding distinct isoforms have been identified, and a related pseudogene is present on chromosome 12.