UBE2K

UBE2K
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YLA, 2O25, 3E46, 3F92, 3K9O, 3K9P, 5DFL
Identifiers
Aliases	UBE2K, E2-25K, HIP2, HYPG, LIG, UBC1, ubiquitin conjugating enzyme E2 K
External IDs	OMIM: 602846; MGI: 1858216; HomoloGene: 3903; GeneCards: UBE2K; OMA:UBE2K - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	39,782,792 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	65,756,331 bp
RNA expression pattern
	Top expressed in
	sperm; ; secondary oocyte; ; islet of Langerhans; ; postcentral gyrus; ; Brodmann area 23; ; middle temporal gyrus; ; amniotic fluid; ; buccal mucosa cell; ; superior frontal gyrus; ; stromal cell of endometrium;
	Top expressed in
	seminiferous tubule; ; zygote; ; tail of embryo; ; primary oocyte; ; primitive streak; ; secondary oocyte; ; abdominal wall; ; genital tubercle; ; yolk sac; ; hair follicle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity; transferase activity; nucleotide binding; ubiquitin-ubiquitin ligase activity; protein binding; ATP binding; ubiquitin protein ligase binding; ubiquitin conjugating enzyme activity;
Cellular component	cytoplasm; filopodium tip; nucleus; cytosol;
Biological process	protein K48-linked ubiquitination; positive regulation of type I interferon-mediated signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; free ubiquitin chain polymerization; positive regulation of peptidyl-threonine phosphorylation; ubiquitin-dependent protein catabolic process; cellular response to interferon-beta; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	3093
	53323
	ENSG00000078140
	ENSMUSG00000029203
	P61086
	P61087
NM_005339; NM_001111112; NM_001111113; NM_001312646; NM_001312647;
	NM_001312648; NM_032733
	NM_016786; NM_001310618; NM_001310619
NP_001104582; NP_001104583; NP_001299575; NP_001299576; NP_001299577;
	NP_005330
	NP_001297547; NP_001297548; NP_058066
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-conjugating enzyme E2 K is a protein that in humans is encoded by the UBE2K gene.

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.