UBA protein domain
| UBA | |||||||
|---|---|---|---|---|---|---|---|
The NMR structure of a UBA domain from the protein ubiquilin-1 (top, cyan) bound to ubiquitin (bottom, orange), illustrating the three-helix bundle structure of the UBA domain. Isoleucine 44, the center of a hydrophobic patch on the ubiquitin surface that interacts with a number of ubiquitin-binding domains, is highlighted in blue. Rendered from PDB: 2JY6. | |||||||
| Identifiers | |||||||
| Symbol | UBA | ||||||
| Pfam | PF00627 | ||||||
| Pfam clan | CL0214 | ||||||
| ECOD | 103.1.1 | ||||||
| InterPro | IPR015940 | ||||||
| PROSITE | PDOC50030 | ||||||
| SCOP2 | 1efu / SCOPe / SUPFAM | ||||||
| CDD | cd00194 | ||||||
| |||||||
Ubiquitin-associated (UBA) domains are protein domains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that is covalently linked to other proteins as part of intracellular signaling pathways, often as a signal for protein degradation. UBA domains are among the most common ubiquitin-binding domains.