U.S. Route 278 in Alabama

U.S. Route 278
U.S. Route 278
State Route 74
	US 278 highlighted in red
Route information
	Auxiliary route of US 78
	Maintained by ALDOT
Length	199.182 mi (320.552 km)
Major junctions
West end	US 278 at the Mississippi state line in Gattman, MS
	US 43 in Guin and Hamilton; I-22 / US 78 near Hamilton; I-65 in Cullman; US 31 in Cullman; US 231 in Blountsville; US 431 west of Attalla; US 11 in Attalla; I-59 in Attalla; US 411 in Gadsden;
East end	US 278 / SR 6 at the Georgia state line near Esom Hill, GA
Location
Country	United States
State	Alabama
Counties	Lamar, Marion, Winston, Cullman, Blount, Etowah, Calhoun, Cherokee, Cleburne
Highway system
	United States Numbered Highway System; List; Special; Divided; Alabama State Highway System; Interstate; US; State;

U.S. Route 278 (US 278), mostly internally designated by the Alabama Department of Transportation as State Route 74 (SR 74), is a major east–west U.S. highway across the northern part of the U.S. state of Alabama. West of Hamilton, SR 74 continues west to end at US 78 (unsigned SR 4), while US 278 turns south along US 43/SR 17/SR 171 to Guin, where it turns west along SR 118 to the Mississippi state line.