Trimethyl orthoformate

Trimethyl orthoformate
Names
	Preferred IUPAC name Trimethoxymethane
	Other names 2-Methoxyacetaldehyde dimethyl acetal; Methoxymethylal; Methyl orthoformate
Identifiers
CAS Number	149-73-5 ;
3D model (JSmol)	Interactive image;
ChemSpider	8655;
ECHA InfoCard	100.005.224
EC Number	205-745-7;
PubChem CID	9005;
UNII	XAM28819YJ ;
CompTox Dashboard (EPA)	DTXSID7027122 ;
	InChI InChI=1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3;
	SMILES O(C)C(OC)OC;
Properties
Chemical formula	C4H10O3
Molar mass	106.121 g·mol−1
Appearance	Colorless liquid
Odor	pungent
Density	0.9676 g/cm3
Melting point	−53 °C (−63 °F; 220 K)
Boiling point	100.6 °C (213.1 °F; 373.8 K)
Solubility	soluble in ethanol, diethyl ether
Vapor pressure	1 kPa at 7 °C
Refractive index (nD)	1.3773
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H225, H315, H319, H335
Precautionary statements	P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, P501
Flash point	13 °C (55 °F; 286 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Trimethyl orthoformate (TMOF) is the organic compound with the formula HC(OCH₃)₃. A colorless liquid, it is the simplest orthoester. It is a reagent used in organic synthesis for the formation of methyl ethers. The product of reaction of an aldehyde with trimethyl orthoformate is an acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.