Transamidation

Transamidation is a chemical reaction in which an amide reacts with an amine to generate a new amide:

RC(O)NR'2 + HNR"2 → RC(O)NR"2 + HNR'2

The reaction is rarely employed, but it could prove relevant to peptide synthesis.

Amides are characteristically inert, but the amino substituents can be exchanged in the presence of Lewis acid and organometallic catalysts. Primary amides (RC(O)NH2) are more amenable to this reaction.

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