Tinofedrine

Tinofedrine
Clinical data
Other names	Novocebrin; D-8955; D8955; N-(3,3-Di-3-thienyl)-2-propenyl)norephedrine; (1R,2S)-β-Hydroxy-N-(3,3-di-3-thienyl)-2-propenyl)amphetamine
Drug class	Sympathomimetic; Cerebral vasodilator
Identifiers
	IUPAC name (1R,2S)-2-[3,3-di(thiophen-3-yl)prop-2-enylamino]-1-phenylpropan-1-ol;
CAS Number	66788-41-8 ; 50776-39-1 (hydrochloride);
PubChem CID	3033341;
ChemSpider	2298059;
UNII	OVJ0W8F17T;
ChEBI	CHEBI:135502;
ChEMBL	ChEMBL3989760;
CompTox Dashboard (EPA)	DTXSID00216907 ;
ECHA InfoCard	100.060.415
Chemical and physical data
Formula	C20H21NOS2
Molar mass	355.51 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]([C@@H](C1=CC=CC=C1)O)NCC=C(C2=CSC=C2)C3=CSC=C3;
	InChI InChI=1S/C20H21NOS2/c1-15(20(22)16-5-3-2-4-6-16)21-10-7-19(17-8-11-23-13-17)18-9-12-24-14-18/h2-9,11-15,20-22H,10H2,1H3/t15-,20-/m0/s1; Key:JQSHEDRVRBSFCZ-YWZLYKJASA-N;

Tinofedrine (INNTooltip International Nonproprietary Name; developmental code name D-8955, proposed brand name Novocebrin), also known as N-(3,3-di-3-thienyl)-2-propenyl)norephedrine, is a sympathomimetic and cerebral vasodilator of the amphetamine family which was never marketed. It is a derivative of norephedrine and an analogue of related agents like oxyfedrine, buphenine (nylidrin), and isoxsuprine. The drug was first described in the literature by 1978.