Timothy A. Springer
Timothy Alan Springer | |
|---|---|
| Born | February 23, 1948 |
| Education | Harvard University (PhD) University of California, Berkeley (BA) |
| Known for | Discovery of LFA-1 and other integrins |
| Awards | Robert Koch Prize Albert Lasker Award for Basic Medical Research Canada Gairdner International Award Crafoord Prize American Society of Hematology Henry M. Stratton Medal Biophysical Society Founders Award Protein Society Stein & Moore Award |
| Scientific career | |
| Fields | Immunology Structural biology Biophysics Biochemistry |
| Institutions | Harvard University Boston Children's Hospital Dana Farber Cancer Institute University of Cambridge MRC Laboratory of Molecular Biology |
| Thesis | Detergent soluble products of HLA (1976) |
| Doctoral advisor | Jack Strominger |
| Website | https://timothyspringer.org |
Timothy "Tim" A. Springer (born February 23, 1948) is an American biochemist, immunologist, and biophysicist known for his foundational work on protein allostery, cell adhesion, vasculature, and immune regulation. He is the Latham Family Professor at Harvard Medical School in the Departments of Pediatrics and of Biological Chemistry and Molecular Pharmacology, and a faculty member in the Program in Cellular and Molecular Medicine and Division of Hematology at the Boston Children’s Hospital (BCH). Springer is best known for discovering the first integrins, LFA-1, and intercellular adhesion molecules (ICAMs), and for elucidating how these cell adhesion molecules function in the immune system. In recent years, his laboratory has expanded to structural and mechanobiological studies of integrins, transforming growth factor β (TGF-β), and synthetic hydrogels designed to enhance organoid fidelity for regenerative medicine and drug discovery.