Theresa Gillespie Isom

Theresa Gillespie Isom
Member of the Mississippi State Senate from the 2nd district
Incumbent
Assumed office
January 6, 2026
Preceded byDavid Parker
Personal details
Born
Memphis, Tennessee, U.S.
PartyDemocratic Party
Occupationpolitician, healthcare administrator, nurse

Theresa Gillespie Isom is an American politician and former healthcare administrator. A Democrat, she was elected to the Mississippi State Senate, representing the 2nd District, which includes parts of DeSoto and Tunica counties. Isom won a special election on November 4, 2025, becoming the first African American and first female senator to represent DeSoto County. Her victory helped break a Republican supermajority in the state senate.

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