TSG101

TSG101
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KPP, 1KPQ, 1M4P, 1M4Q, 1S1Q, 2F0R, 3IV1, 3OBQ, 3OBS, 3OBU, 3OBX, 3P9G, 3P9H, 4EJE, 4YC1, 4ZNY
Identifiers
Aliases	TSG101, TSG10, VPS23, tumor susceptibility 101
External IDs	OMIM: 601387; MGI: 106581; HomoloGene: 4584; GeneCards: TSG101; OMA:TSG101 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,526,951 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,569,717 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; ganglionic eminence; ; islet of Langerhans; ; amniotic fluid; ; gingival epithelium; ; gastrocnemius muscle; ; rectum; ; parotid gland;
	Top expressed in
	tail of embryo; ; ganglionic eminence; ; ventricular zone; ; genital tubercle; ; maxillary prominence; ; mandibular prominence; ; neural tube; ; medial ganglionic eminence; ; neural layer of retina; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; transcription corepressor activity; calcium-dependent protein binding; ubiquitin binding; protein binding; nuclear receptor coactivator activity; virion binding; ubiquitin protein ligase binding; protein-containing complex binding;
Cellular component	cytoplasm; multivesicular body; endosome; late endosome; membrane; late endosome membrane; plasma membrane; early endosome; nucleolus; endosome membrane; extracellular exosome; ESCRT I complex; nucleus; cytosol; host cell; microtubule organizing center; cytoskeleton; early endosome membrane; Flemming body;
Biological process	intracellular transport of virus; cell differentiation; positive regulation of ubiquitin-dependent endocytosis; regulation of extracellular exosome assembly; viral budding via host ESCRT complex; viral life cycle; endosome to lysosome transport; multivesicular body assembly; protein monoubiquitination; viral budding; keratinocyte differentiation; cell division; endosomal transport; autophagosome maturation; regulation of cell growth; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; regulation of MAP kinase activity; positive regulation of exosomal secretion; cell cycle; regulation of growth; negative regulation of transcription, DNA-templated; negative regulation of cell population proliferation; viral process; exosomal secretion; macroautophagy; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; transport; extracellular transport; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	7251
	22088
	ENSG00000074319
	ENSMUSG00000014402
	Q99816
	Q61187
	NM_006292
	NM_021884; NM_001348088; NM_001348089
	NP_006283
	NP_068684; NP_001335017; NP_001335018
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.