TSEN15

Tsen15
Identifiers
Aliases	5730449L18RikAL023077Sen15tRNA splicing endonuclease subunit 15
External IDs	HomoloGene: 12002; GeneCards: [1]; OMA:- orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	152,262,439 bp
RNA expression pattern
	Top expressed in
	yolk sac; ; epiblast; ; embryo; ; ventricular zone; ; embryo; ; quadriceps femoris muscle; ; olfactory bulb; ; placenta; ; heart; ; skeletal muscle tissue;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA-intron endonuclease activity; molecular function; nucleic acid binding; nuclease activity;
Cellular component	nucleolus; nucleus; cellular component;
Biological process	mRNA processing; tRNA splicing, via endonucleolytic cleavage and ligation; RNA phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA processing; biological process; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	66637
	n/a
	ENSMUSG00000014980
	n/a
	Q8R3W5
	Q8R3W5
	NM_025677
	n/a
	NP_079953
	NP_079953
	Wikidata
View/Edit Human

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]