Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.
The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Recent research has showed that TRIM16 acts as an E3 ubiquitin ligase and molecular scaffold that participates in protein-quality control, tumor suppression, and protection against cardiac hypertrophy. TRIM16 is expressed in many tissues and participates in cellular pathways that maintain proteostasis and regulate stress responses.