TREX1

TREX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IOC, 2O4G, 2O4I, 2OA8, 3B6O, 3B6P, 3MXI, 3MXJ, 3MXM, 3U3Y, 3U6F, 4YNQ
Identifiers
Aliases	TREX1, AGS1, CRV, DRN3, HERNS, three prime repair exonuclease 1, RVCLS
External IDs	OMIM: 606609; MGI: 1328317; HomoloGene: 7982; GeneCards: TREX1; OMA:TREX1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,467,645 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,888,802 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; granulocyte; ; monocyte; ; spleen; ; skin of abdomen; ; skin of leg; ; anterior pituitary; ; blood; ; salivary gland; ; minor salivary glands;
	Top expressed in
	lens; ; spleen; ; urinary bladder; ; quadriceps femoris muscle; ; adrenal gland; ; bone marrow; ; granulocyte; ; muscle tissue; ; muscle of thigh; ; white adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; metal ion binding; single-stranded DNA binding; exodeoxyribonuclease III activity; MutSalpha complex binding; protein binding; 3'-5'-exodeoxyribonuclease activity; MutLalpha complex binding; nucleic acid binding; nuclease activity; exonuclease activity; hydrolase activity; 3'-5' exonuclease activity; double-stranded DNA binding; adenyl deoxyribonucleotide binding; magnesium ion binding; DNA binding; DNA binding, bending; WW domain binding;
Cellular component	cytoplasm; nuclear envelope; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nucleus; cytosol; oligosaccharyltransferase complex; protein-DNA complex; nuclear replication fork;
Biological process	DNA recombination; regulation of type I interferon production; DNA replication; DNA mismatch repair; nucleic acid phosphodiester bond hydrolysis; DNA metabolic process; DNA repair; cellular response to interferon-beta; blood vessel development; kidney development; adaptive immune response; organ or tissue specific immune response; activation of immune response; macrophage activation involved in immune response; lymphoid progenitor cell differentiation; immune response in brain or nervous system; inflammatory response to antigenic stimulus; T cell antigen processing and presentation; regulation of immunoglobulin production; heart morphogenesis; heart process; atrial cardiac muscle tissue development; generation of precursor metabolites and energy; regulation of glycolytic process; DNA modification; DNA catabolic process; inflammatory response; immune response; cellular response to DNA damage stimulus; determination of adult lifespan; response to UV; regulation of gene expression; regulation of fatty acid metabolic process; regulation of cellular metabolic process; transposition, RNA-mediated; DNA duplex unwinding; interferon-alpha production; regulation of tumor necrosis factor production; cellular response to oxidative stress; cellular response to reactive oxygen species; cellular response to UV; CD86 biosynthetic process; apoptotic cell clearance; regulation of cellular respiration; innate immune response; regulation of innate immune response; establishment of protein localization; regulation of lipid biosynthetic process; regulation of inflammatory response; regulation of catalytic activity; protein stabilization; regulation of T cell activation; defense response to virus; type I interferon signaling pathway; negative regulation of type I interferon-mediated signaling pathway; regulation of protein complex stability; cellular response to organic substance; cellular response to type I interferon; cellular response to gamma radiation; cellular response to hydroxyurea; immune complex formation; DNA synthesis involved in UV-damage excision repair; regulation of lysosome organization;
	Sources:Amigo / QuickGO
Orthologs
	11277
	22040
	ENSG00000213689
	ENSMUSG00000049734
	Q9NSU2
	Q91XB0
	NM_033629; NM_007248; NM_016381; NM_033627; NM_033628
	NM_001012236; NM_011637
	NP_009179; NP_338599
	NP_001012236; NP_035767
	Wikidata
View/Edit Human	View/Edit Mouse

Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene.