TRAF2

TRAF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3M0D, 1CA4, 1CA9, 1CZY, 1CZZ, 1D00, 1D01, 1D0A, 1D0J, 1F3V, 1QSC, 3KNV, 3M06, 3M0A
Identifiers
Aliases	TRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
External IDs	OMIM: 601895; MGI: 101835; HomoloGene: 22520; GeneCards: TRAF2; OMA:TRAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,926,607 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,436,952 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; lymph node; ; right testis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; left testis; ; ganglionic eminence; ; gonad; ; spleen;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; lactiferous gland; ; spermatocyte; ; crypt of lieberkuhn of small intestine; ; intestinal villus; ; spleen; ; right kidney; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingolipid binding; lipid binding; CD40 receptor binding; mitogen-activated protein kinase kinase kinase binding; zinc ion binding; signal transducer activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; identical protein binding; thioesterase binding; enzyme binding; protein phosphatase binding; protein kinase binding; ubiquitin protein ligase binding; transferase activity; tumor necrosis factor receptor binding; protein-containing complex binding;
Cellular component	TRAF2-GSTP1 complex; AIP1-IRE1 complex; ubiquitin ligase complex; vesicle membrane; cell cortex; membrane raft; CD40 receptor complex; cytoplasmic side of plasma membrane; IRE1-TRAF2-ASK1 complex; nucleoplasm; cytoplasm; cytosol; protein-containing complex;
Biological process	regulation of apoptotic process; positive regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of JUN kinase activity; negative regulation of glial cell apoptotic process; regulation of tumor necrosis factor-mediated signaling pathway; protein K63-linked ubiquitination; positive regulation of DNA-binding transcription factor activity; tumor necrosis factor-mediated signaling pathway; activation of NF-kappaB-inducing kinase activity; positive regulation of protein homodimerization activity; response to endoplasmic reticulum stress; protein homotrimerization; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of I-kappaB phosphorylation; regulation of JNK cascade; protein catabolic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of interleukin-2 production; death-inducing signaling complex assembly; positive regulation of T cell cytokine production; protein ubiquitination; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of extrinsic apoptotic signaling pathway; cellular response to nitric oxide; regulation of extrinsic apoptotic signaling pathway via death domain receptors; I-kappaB kinase/NF-kappaB signaling; activation of cysteine-type endopeptidase activity involved in apoptotic process; signal transduction; protein autoubiquitination; negative regulation of neuron death; programmed necrotic cell death; apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein deubiquitination; protein heterooligomerization; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	7186
	22030
	ENSG00000127191
	ENSMUSG00000026942
	Q12933
	P39429
	NM_021138
	NM_009422; NM_001290413
	NP_066961
	NP_001277342; NP_033448
	Wikidata
View/Edit Human	View/Edit Mouse

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.