TMEM51

TMEM51
Identifiers
Aliases	TMEM51, C1orf72, transmembrane protein 51
External IDs	MGI: 2384874; HomoloGene: 9966; GeneCards: TMEM51; OMA:TMEM51 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	15,220,478 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,811,615 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; oocyte; ; body of stomach; ; cartilage tissue; ; mucosa of transverse colon; ; stromal cell of endometrium; ; gallbladder; ; buccal mucosa cell; ; islet of Langerhans; ; right adrenal cortex;
	Top expressed in
	stomach; ; right kidney; ; proximal tubule; ; ileum; ; duodenum; ; yolk sac; ; jejunum; ; human kidney; ; urinary bladder; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	membrane; integral component of membrane; cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	55092
	214359
	ENSG00000171729
	ENSMUSG00000040616
	Q9NW97; Q9BSA0
	Q99LG1
	NM_001136216; NM_001136217; NM_001136218; NM_018022; NM_001319665
	NM_145402
NP_001129688; NP_001129689; NP_001129690; NP_001306594; NP_060492;
	NP_001306594.1
	NP_663377
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene. It is located on the first chromosome (1p36.21) and has 6 isoforms in humans. It has orthologs in mammals, birds, reptiles, amphibians, and fish.

It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence.

TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression. Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome.