PARP7

TIPARP
Identifiers
EC no.2.4.2.-
CAS no.Not applicable
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Poly [ADP-ribose] polymerase 7 (PARP7), also known as TCDD-inducible poly-ADP-ribose polymerase (TIPARP), is an enzyme of the PARP family that catalyzes the transfer of ADP-ribose from NAD+ to specific amino acids of itself and other substrate proteins. It is encoded by the TIPARP gene on chromosome 3. The 17 members of the PARP family are divided into polyPARPs, monoPARPs, and PARPs without catalytic activity according to different catalytic functions. PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. PARP7 is involved in tumor generation and immune function recovery.