TGF-8027

TGF-8027
Clinical data
Other namesTGF8027; TGF-8-027; N-[1-(2-Hydroxyphenyl)ethyl]-2,5-dimethoxy-4-cyanophenethylamine
Drug classSelective serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Chemical and physical data
FormulaC19H22N2O3
Molar mass326.396 g·mol−1
3D model (JSmol)
  • C1=C(C#N)C(OC)=CC(CCN([H])C(C)C2=CC=CC=C2O[H])=C1OC
  • InChI=1S/C19H22N2O3/c1-13(16-6-4-5-7-17(16)22)21-9-8-14-10-19(24-3)15(12-20)11-18(14)23-2/h4-7,10-11,13,21-22H,8-9H2,1-3H3
  • Key:YGVDYCKUVCKBFS-UHFFFAOYSA-N

TGF-8027, or TGF-8-027, also known as N-[1-(2-hydroxyphenyl)ethyl]-2,5-dimethoxy-4-cyanophenethylamine, is a highly selective serotonin 5-HT2A receptor agonist and putative serotonergic psychedelic of the phenethylamine, 2C, and 25-NB (NBOH) families. It is one of the most selective serotonin 5-HT2A receptor agonists known and shows much greater selectivity than earlier agents like 25CN-NBOH, DMBMPP, and LPH-5. The drug produces psychedelic-like effects in rodents and hence may be hallucinogenic in humans. TGF-8027 was first described in the literature in 2025.

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