TCIRG1

TCIRG1
Identifiers
Aliases	TCIRG1, ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3, T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3, T cell immune regulator 1, ATPase H+ transporting V0 subunit a3
External IDs	OMIM: 604592; MGI: 1350931; HomoloGene: 4392; GeneCards: TCIRG1; OMA:TCIRG1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,050,895 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,957,133 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; spleen; ; body of pancreas; ; right adrenal cortex; ; left adrenal cortex; ; canal of the cervix; ; gastric mucosa; ; upper lobe of left lung; ; right lung;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; body of femur; ; thymus; ; decidua; ; internal carotid artery; ; tibiofemoral joint; ; mesenteric lymph nodes; ; external carotid artery; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; ATPase binding; proton-transporting ATPase activity, rotational mechanism; proton transmembrane transporter activity;
Cellular component	integral component of membrane; proton-transporting V-type ATPase, V0 domain; phagocytic vesicle membrane; membrane; vacuolar proton-transporting V-type ATPase, V0 domain; plasma membrane; integral component of plasma membrane; lysosomal membrane; apical plasma membrane; mitochondrion; vacuolar proton-transporting V-type ATPase complex; endosome membrane; ficolin-1-rich granule membrane; nucleus; lysosome; late endosome; secretory granule membrane; phagocytic vesicle;
Biological process	protein catabolic process in the vacuole; insulin receptor signaling pathway; transferrin transport; vacuolar proton-transporting V-type ATPase complex assembly; ion transport; vacuolar acidification; cellular defense response; ion transmembrane transport; positive regulation of cell population proliferation; ATP synthesis coupled proton transport; macroautophagy; phagosome acidification; neutrophil degranulation; transport; proton transmembrane transport; ossification; osteoclast proliferation; immunoglobulin production; cellular calcium ion homeostasis; apoptotic process; inflammatory response; regulation of proton transport; response to silver ion; regulation of gene expression; immunoglobulin mediated immune response; optic nerve development; myeloid cell differentiation; B cell differentiation; T cell differentiation; osteoclast differentiation; memory T cell activation; T-helper 1 cell activation; odontogenesis; T cell homeostasis; tooth eruption; bone resorption; regulation of osteoblast differentiation; pH reduction; homeostasis of number of cells; regulation of insulin secretion; retina development in camera-type eye; hematopoietic stem cell homeostasis; enamel mineralization; cellular response to cytokine stimulus; dentin mineralization;
	Sources:Amigo / QuickGO
Orthologs
	10312
	27060
	ENSG00000110719
	ENSMUSG00000001750
	Q13488
	n/a
	NM_006019; NM_006053; NM_001351059
	NM_001136091; NM_001167784; NM_016921
	NP_006010; NP_006044; NP_001337988
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

The TCIRG1 (T cell immune regulator 1) gene encodes for the V-type proton ATPase (V-ATPase) 116 kDa subunit a isoform 3 enzyme.