TATA-binding protein

Available protein structures:
PDB	IPR000814 PF00352 (ECOD; PDBsum)
AlphaFold	IPR000814; PF00352;

TBP
TBP
	crystal structure of a yeast brf1-tbp-dna ternary complex
Identifiers
Symbol	TBP
Pfam	PF00352
Pfam clan	CL0407
InterPro	IPR000814
PROSITE	PDOC00303
SCOP2	1tbp / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR000814 PF00352 (ECOD; PDBsum)
AlphaFold	IPR000814; PF00352;

TBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TGH, 1C9B, 1JFI, 1NVP, 4ROC, 4ROE, 4ROD, 5IY9, 5IYA, 5FUR, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6
Identifiers
Aliases	TBP, GTF2D, GTF2D1, HDL4, SCA17, TFIID, TATA-box binding protein, TATA-binding protein, TBP1
External IDs	OMIM: 600075; MGI: 101838; HomoloGene: 2404; GeneCards: TBP; OMA:TBP - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	170,572,870 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,748,641 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; oocyte; ; gonad; ; granulocyte; ; sperm; ; secondary oocyte; ; mucosa of transverse colon; ; middle temporal gyrus; ; sural nerve;
	Top expressed in
	tail of embryo; ; spermatocyte; ; zygote; ; genital tubercle; ; neural layer of retina; ; secondary oocyte; ; spermatid; ; seminiferous tubule; ; ventricular zone; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; DNA-binding transcription factor activity; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; enzyme binding; TFIIB-class transcription factor binding; aryl hydrocarbon receptor binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase III general transcription initiation factor activity; RNA polymerase II general transcription initiation factor activity; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase III transcription regulatory region sequence-specific DNA binding;
Cellular component	cytoplasm; transcription factor TFIID complex; male pronucleus; female pronucleus; nucleoplasm; transcription factor TFIIA complex; pronucleus; nucleus; transcription preinitiation complex; protein-containing complex; transcription factor TFIIIB complex; transcription regulator complex;
Biological process	termination of RNA polymerase I transcription; epigenetic maintenance of chromatin in transcription-competent conformation; regulation of transcription, DNA-templated; transcription initiation from RNA polymerase I promoter; transcription, DNA-templated; positive regulation of transcription, DNA-templated; spermatogenesis; DNA-templated transcription, initiation; transcription initiation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II; regulation of signal transduction by p53 class mediator; viral process; regulation of transcription by RNA polymerase III; transcription by RNA polymerase II; transcription by RNA polymerase III; RNA polymerase II preinitiation complex assembly; regulation of transcription by RNA polymerase II; RNA polymerase III preinitiation complex assembly; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	6908
	21374
	ENSG00000112592
	ENSMUSG00000014767
	P20226
	P29037
	NM_003194; NM_001172085
	NM_013684
	NP_001165556; NP_003185
	NP_038712
	Wikidata
View/Edit Human	View/Edit Mouse

The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.