TAP2

TAP2
Identifiers
Aliases	TAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDs	OMIM: 170261; MGI: 98484; HomoloGene: 37323; GeneCards: TAP2; OMA:TAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,838,739 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,435,295 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; monocyte; ; granulocyte; ; duodenum; ; apex of heart; ; spleen; ; stromal cell of endometrium; ; mucosa of transverse colon; ; blood;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; lactiferous gland; ; spleen; ; duodenum; ; subcutaneous adipose tissue; ; jejunum; ; bone marrow; ; submandibular gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	MHC protein binding; ATPase-coupled transmembrane transporter activity; nucleotide binding; ABC-type peptide transporter activity; transporter activity; tapasin binding; MHC class Ib protein binding; ABC-type peptide antigen transporter activity; ATPase activity; protein binding; TAP1 binding; ATP binding; peptide transmembrane transporter activity; MHC class I protein binding; TAP2 binding;
Cellular component	TAP complex; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; integral component of membrane; endoplasmic reticulum; nuclear speck; phagocytic vesicle membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; MHC class I peptide loading complex;
Biological process	adaptive immune response; immune system process; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; transmembrane transport; protein transport; peptide transport; viral process; cytosol to endoplasmic reticulum transport; antigen processing and presentation of endogenous peptide antigen via MHC class I; peptide antigen transport; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; transport;
	Sources:Amigo / QuickGO
Orthologs
	6891
	21355
ENSG00000204267; ENSG00000206299; ENSG00000228582; ENSG00000206235; ENSG00000225967;
	ENSG00000237599; ENSG00000223481; ENSG00000232326
	ENSMUSG00000024339
	Q03519
	P36371
	NM_018833; NM_000544; NM_001290043
	NM_011530
	NP_000535; NP_001276972; NP_061313
	NP_035660
	Wikidata
View/Edit Human	View/Edit Mouse

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.