TAAR9

TAAR9
Identifiers
Aliases	TAAR9, TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9
External IDs	OMIM: 608282; MGI: 3527454; HomoloGene: 65286; GeneCards: TAAR9; OMA:TAAR9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,539,336 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,985,432 bp
RNA expression pattern
	Top expressed in
	material anatomical entity;
	Top expressed in
	embryo; ; primary oocyte; ; secondary oocyte; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; trace-amine receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	134860
	503558
	ENSG00000237110
	ENSMUSG00000037424
	Q96RI9
	Q5QD04
	NM_175057
	NM_001010831
	NP_778227
	NP_001010831
	Wikidata
View/Edit Human	View/Edit Mouse

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.

TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.

Recent research has demonstrated that deletion of the TAAR9 gene in rats leads to significant changes in both the CNS and the periphery. In the central nervous system, knockout of this gene slightly increases hippocampal serotonin and alters grooming behavior. Peripherally, blood analysis revealed decreased levels of low-density lipoprotein cholesterol in the blood. Additionally, TAAR9 appears to play a significant role in maintaining microbiota homeostasis. In TAAR9-KO rats, the microbiome structure exhibited greater variability than in wild-type littermates.