Synucleinopathy

Synucleinopathy
Other namesα-synucleinopathies
Positive α-synuclein staining (brown) of a Lewy body in the substantia nigra of an individual with Parkinson's disease
SpecialtyNeurology
SymptomsAutonomic dysfunction, motor impairments, cognitive and sleep issues, parkinsonism, memory loss, hallucinations
DurationLong term
TypesParkinson's disease, dementia with Lewy bodies, multiple system atrophy
CausesUnknown

Synucleinopathies are neurodegenerative diseases characterised by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. The synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Other rare disorders, such as various neuroaxonal dystrophies, also have α-synuclein pathologies.

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