Sultiame

Sultiame
	Molecular structure of sulthiame
	3D representation of a sulthiame molecule
Clinical data
Trade names	Ospolot
Other names	Sulthiame, Sulthiame (AAN AU), sulthiame (USAN US)
AHFS/Drugs.com	International Drug Names
Pregnancy; category	AU: D; ;
Routes of; administration	Oral
Drug class	Anticonvulsant; Carbonic anhydrase inhibitor
ATC code	N03AX03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	100% (oral)
Protein binding	29%
Metabolism	Hepatic secretion
Elimination half-life	24 hours
Excretion	Fecal (10%) and renal (90%)
Identifiers
	IUPAC name 4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide;
CAS Number	61-56-3 ;
PubChem CID	5356;
DrugBank	DB08329 ;
ChemSpider	5163 ;
UNII	I00Q766CZ2;
KEGG	D01787 ;
ChEMBL	ChEMBL328560 ;
CompTox Dashboard (EPA)	DTXSID4023626 ;
ECHA InfoCard	100.000.465
Chemical and physical data
Formula	C10H14N2O4S2
Molar mass	290.35 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S2(=O)N(c1ccc(cc1)S(=O)(=O)N)CCCC2;
	InChI InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) ; Key:HMHVCUVYZFYAJI-UHFFFAOYSA-N ;
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Sultiame, or sulthiame, sold under the brand name Ospolot among others, is a sulfonamide and inhibitor of the enzyme carbonic anhydrase which is used as an anticonvulsant in the treatment of epilepsy. In addition to its use as an antiepileptic medication, recent studies showed promise in reducing sleep disordered breathing and other symptoms of obstructive sleep apnea (OSA).