Speedball (drug)

Speedball, powerball, or over and under is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, methamphetamine mixed with morphine and/or fentanyl has also been used. A speedball may be taken intravenously or by nasal insufflation.

Speedballs often give stronger effects than either drug when taken alone due to drug synergy, but are a particularly hazardous mixture that can easily cause heart attack, respiratory arrest and death. When compared to single drugs, speedballs are more likely to lead to addiction, relapse and overdose.