Sorting nexin

PX domain
Structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
Identifiers
SymbolPX
PfamPF00787
InterProIPR001683
SMARTPX
PROSITEPDOC50195
SCOP21h6h / SCOPe / SUPFAM
OPM superfamily57
OPM protein4on3
Available protein structures:
PDB  IPR001683 PF00787 (ECOD; PDBsum)  
AlphaFold
Sorting nexin, N-terminal domain
Identifiers
SymbolSorting_nexin
PfamPF03700
InterProIPR005329
Available protein structures:
PDB  IPR005329 PF03700 (ECOD; PDBsum)  
AlphaFold
Vps5 C terminal like (BAR domain)
Identifiers
SymbolVps5
PfamPF09325
InterProIPR015404
Available protein structures:
PDB  IPR015404 PF09325 (ECOD; PDBsum)  
AlphaFold
Sorting nexin, C terminal domain
Identifiers
SymbolNexin_C
PfamPF08628
InterProIPR013937
Available protein structures:
PDB  IPR013937 PF08628 (ECOD; PDBsum)  
AlphaFold
WASP-binding domain of Sorting nexin protein
Identifiers
SymbolBAR3-WASP
PfamPF10456
Available protein structures:
PDB  PF10456 (ECOD; PDBsum)  
AlphaFold

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

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