Small fiber neuropathy

Small fiber peripheral neuropathy is a type of peripheral neuropathy that results from damage to the small unmyelinated and myelinated peripheral nerve fibers. These fibers, categorized as C fibers and small Aδ fibers, are present throughout human skin, peripheral nerves, and organs. Small fiber nerves receive somatic afferent signals (somatic afferents) and regulate components of the autonomic nervous system (autonomic efferents). It is estimated that 15–20 million people in the United States have some form of peripheral neuropathy.