Signal recognition particle receptor

Signal recognition particle (SRP) receptor alpha subunit, N-terminal
Structure of the beta subunit of the eukaryotic signal recognition particle receptor.
Identifiers
SymbolSRX
PfamPF09201
InterProIPR015284
SCOP21nrj / SCOPe / SUPFAM
OPM superfamily136
OPM protein1nrj
Membranome38
Available protein structures:
PDB  IPR015284 PF09201 (ECOD; PDBsum)  
AlphaFold

Signal recognition particle (SRP) receptor, also called the docking protein, is a dimer composed of 2 different subunits that are associated exclusively with the rough ER in mammalian cells. Its main function is to identify the SRP units. SRP (signal recognition particle) is a molecule that helps the ribosome-mRNA-polypeptide complexes to settle down on the membrane of the endoplasmic reticulum.

The eukaryotic SRP receptor (termed SR) is a heterodimer of SR-alpha (70 kDa; SRPRA) and SR-beta (25 kDa; SRPRB), both of which contain a GTP-binding domain, while the prokaryotic SRP receptor comprises only the monomeric loosely membrane-associated SR-alpha homologue FtsY (P10121).

This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.