Second ladies and gentlemen of Colombia

The second gentleman of Colombia or second lady (second gentleman of the nation) it is the informal and unofficial title held by the spouse of the Vice President of Colombia, simultaneously with the Vice President's term of office. Coined in contrast to "first lady"—though less frequently used—the "second lady" term's origin is not clearly documented, but María Victoria García de Santos (wife of Francisco Santos Calderón, vice president from 2002 to 2010) is generally considered the title's originator, given her prominent role during Álvaro Uribe's presidency. The first second gentleman of Colombia was Álvaro Rincón, husband of Marta Lucía Ramírez, vice president from 2018 to 2022.

Three second ladies became first ladies during their husbands' presidential terms. The first was Ana de Narváez de Caro, wife of Miguel Antonio Caro, second vice president (1892-1894) and sixth president (1894-1898). The most recent was María Antonia Ferrero de González, wife of Ramón González Valencia, fourth vice president (1904-1905) and eleventh president (1909-1910).

Since the 1990s, the vice presidential official residence is the Vice Presidential House in Bogotá, D.C.