SNCAIP

SNCAIP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KES
Identifiers
Aliases	SNCAIP, SYPH1, Sph1, synuclein alpha interacting protein
External IDs	OMIM: 603779; MGI: 1915097; HomoloGene: 3987; GeneCards: SNCAIP; OMA:SNCAIP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	122,464,219 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	53,049,007 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; germinal epithelium; ; periodontal fiber; ; endometrium; ; parietal pleura; ; stromal cell of endometrium; ; epithelium of bronchus; ; bronchial epithelial cell; ; myometrium;
	Top expressed in
	genital tubercle; ; ventricular zone; ; ganglionic eminence; ; lumbar subsegment of spinal cord; ; external carotid artery; ; saccule; ; internal carotid artery; ; neural tube; ; Rostral migratory stream; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; identical protein binding;
Cellular component	cytoplasm; cytosol; soma; presynaptic membrane; synaptic vesicle; nucleoplasm; cytoplasmic ribonucleoprotein granule;
Biological process	regulation of inclusion body assembly; dopamine metabolic process; cell death; regulation of neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	9627
	67847
	ENSG00000064692
	ENSMUSG00000024534
	Q9Y6H5
	Q99ME3
NM_001242935; NM_001308100; NM_001308105; NM_001308106; NM_001308107;
	NM_001308108; NM_001308109; NM_005460
	NM_001199151; NM_001199153; NM_001199154; NM_026408
NP_001229864; NP_001295029; NP_001295034; NP_001295035; NP_001295036;
	NP_001295037; NP_001295038; NP_005451
NP_001186080; NP_001186082; NP_001186083; NP_080684; NP_001390575;
	NP_001390576; NP_001390577
	Wikidata
View/Edit Human	View/Edit Mouse

Synphilin-1 is a protein that in humans is encoded by the SNCAIP gene. SNCAIP stands for "synuclein, alpha interacting protein".

Synphilin-1 is a cytosolic protein first identified in 1999 as a novel binding partner of α-synuclein, localized within Lewy bodies in Parkinson's disease brain tissue. Experimental studies in mammalian cells and yeast demonstrated that co-expression of synphilin-1 with α-synuclein promotes the formation of cytoplasmic inclusions resembling Lewy bodies.