SNAP25

SNAP25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KIL, 1XTG, 3DDA, 3RK2, 3RK3, 3RL0, 3ZUR, 2N1T, 3DDB
Identifiers
Aliases	SNAP25, CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, bA416N4.2, dJ1068F16.2, SUP, synaptosome associated protein 25kDa, synaptosome associated protein 25
External IDs	OMIM: 600322; MGI: 98331; HomoloGene: 13311; GeneCards: SNAP25; OMA:SNAP25 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	10,308,258 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	136,624,348 bp
RNA expression pattern
	Top expressed in
	pons; ; cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; superior frontal gyrus; ; Brodmann area 23; ; orbitofrontal cortex; ; primary visual cortex; ; lateral nuclear group of thalamus;
	Top expressed in
	cerebellar vermis; ; lobe of cerebellum; ; pontine nuclei; ; medial dorsal nucleus; ; medial vestibular nucleus; ; subiculum; ; prefrontal cortex; ; lateral geniculate nucleus; ; primary motor cortex; ; medial geniculate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	SNAP receptor activity; calcium-dependent protein binding; protein binding; SNARE binding; syntaxin-1 binding; voltage-gated potassium channel activity; syntaxin binding;
Cellular component	cytoplasm; vesicle; cytosol; membrane; growth cone; myelin sheath; BLOC-1 complex; voltage-gated potassium channel complex; plasma membrane; synapse; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; cell junction; trans-Golgi network; SNARE complex; perinuclear region of cytoplasm; neuron projection; synaptic vesicle; presynaptic membrane; axon; specific granule membrane; somatodendritic compartment; tertiary granule membrane; postsynapse; extrinsic component of cytoplasmic side of plasma membrane; cytoskeleton; glutamatergic synapse;
Biological process	associative learning; regulation of neuron projection development; synaptic vesicle docking; locomotory behavior; regulation of insulin secretion; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; glutamate secretion; neurotransmitter uptake; synaptic vesicle priming; regulation of establishment of protein localization; neurotransmitter secretion; long-term potentiation; chemical synaptic transmission; positive regulation of synaptic plasticity; neutrophil degranulation; short-term synaptic potentiation; exocytic insertion of neurotransmitter receptor to postsynaptic membrane; neurotransmitter receptor internalization; exocytosis; vesicle fusion; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6616
	20614
	ENSG00000132639
	ENSMUSG00000027273
	P60880
	P60879
NM_003081; NM_130811; NM_001322902; NM_001322903; NM_001322904;
	NM_001322905; NM_001322906; NM_001322907; NM_001322908; NM_001322909; NM_001322910
	NM_011428; NM_001291056; NM_001355254; NM_001355255
NP_001309831; NP_001309832; NP_001309833; NP_001309834; NP_001309835;
	NP_001309836; NP_001309837; NP_001309838; NP_001309839; NP_003072; NP_570824
	NP_001277985; NP_035558; NP_001342183; NP_001342184
	Wikidata
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Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.