SETD2

SETD2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A7O, 2MDC, 2MDI, 2MDJ, 4FMU, 4H12
Identifiers
Aliases	SETD2, HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP, HSPC069, LLS, SET domain containing 2
External IDs	OMIM: 612778; MGI: 1918177; HomoloGene: 56493; GeneCards: SETD2; OMA:SETD2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	47,163,967 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	110,618,633 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; endothelial cell; ; epithelium of colon; ; Achilles tendon; ; ventricular zone; ; sural nerve; ; pancreatic ductal cell; ; ganglionic eminence; ; internal globus pallidus; ; tonsil;
	Top expressed in
	hand; ; genital tubercle; ; tail of embryo; ; ventricular zone; ; morula; ; neural layer of retina; ; granulocyte; ; mesenteric lymph nodes; ; thymus; ; epiblast;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; protein binding; histone-lysine N-methyltransferase activity; protein-lysine N-methyltransferase activity; alpha-tubulin binding; histone methyltransferase activity (H3-K36 specific); metal ion binding;
Cellular component	nucleoplasm; nucleus; chromosome;
Biological process	regulation of transcription, DNA-templated; histone H3-K36 dimethylation; regulation of mRNA export from nucleus; embryonic organ development; stem cell development; embryonic placenta morphogenesis; transcription elongation from RNA polymerase II promoter; coronary vasculature morphogenesis; cell migration involved in vasculogenesis; morphogenesis of a branching structure; transcription, DNA-templated; mesoderm morphogenesis; vasculogenesis; histone H3-K36 methylation; methylation; neural tube closure; nucleosome organization; angiogenesis; pericardium development; regulation of gene expression; histone H3-K36 trimethylation; embryonic cranial skeleton morphogenesis; DNA mismatch repair; histone lysine methylation; forebrain development; regulation of double-strand break repair via homologous recombination; peptidyl-lysine trimethylation; peptidyl-lysine monomethylation; regulation of cytokinesis; positive regulation of interferon-alpha production; response to type I interferon; endodermal cell differentiation; stem cell differentiation; microtubule cytoskeleton organization involved in mitosis; regulation of protein localization to chromatin; immune system process; DNA repair; cellular response to DNA damage stimulus; multicellular organism development; cell differentiation; innate immune response; defense response to virus; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	29072
	235626
	ENSG00000181555
	ENSMUSG00000044791
	Q9BYW2
	E9Q5F9
	NM_012271; NM_014159; NM_001349370
	NM_001081340
	NP_054878; NP_001336299
	NP_001074809
	Wikidata
View/Edit Human	View/Edit Mouse

SET domain containing 2 is an enzyme that in humans is encoded by the SETD2 gene.