SETD1A

SETD1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S8S, 3UVN, 4EWR
Identifiers
Aliases	SETD1A, KMT2F, Set1, Set1A, SET domain containing 1A, SET domain containing 1A, histone lysine methyltransferase, EPEDD, NEDSID
External IDs	OMIM: 611052; MGI: 2446244; HomoloGene: 52251; GeneCards: SETD1A; OMA:SETD1A - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,984,664 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,399,294 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; sural nerve; ; parotid gland; ; middle frontal gyrus; ; Brodmann area 10; ; right testis; ; left testis; ; dorsal motor nucleus of vagus nerve; ; granulocyte; ; gastrocnemius muscle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; secondary oocyte; ; zygote; ; Rostral migratory stream; ; tibiofemoral joint; ; neural layer of retina; ; cumulus cell; ; muscle of thigh; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	methyltransferase activity; transferase activity; beta-catenin binding; protein binding; RNA binding; nucleic acid binding; histone-lysine N-methyltransferase activity; transcription factor binding; histone methyltransferase activity (H3-K4 specific); euchromatin binding;
Cellular component	chromosome; nucleus; histone methyltransferase complex; nucleoplasm; nuclear speck; Set1C/COMPASS complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; methylation; histone H3-K4 methylation; regulation of hematopoietic stem cell differentiation; regulation of megakaryocyte differentiation; histone lysine methylation; regulation of chromatin organization; chromatin organization; positive regulation of gene expression; stem cell population maintenance; regulation of erythrocyte differentiation; positive regulation of neural precursor cell proliferation; positive regulation of stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9739
	233904
	ENSG00000099381
	ENSMUSG00000042308
	O15047
	E9PYH6
	NM_014712
	NM_010940; NM_178029
	NP_055527
	NP_821172
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase SETD1A is a protein that serves as a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at the lysine 4 residue (K4). SETD1A is highly homologous with SETDB1 but has a distinct subnuclear distribution.