SB-399885

SB-399885
Identifiers
	IUPAC name N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide;
CAS Number	402713-80-8 ;
PubChem CID	6918649;
IUPHAR/BPS	3241;
ChemSpider	5293842;
UNII	5BH7TN3FWY;
ChEMBL	ChEMBL1210710 ;
CompTox Dashboard (EPA)	DTXSID60437717 ;
Chemical and physical data
Formula	C18H21Cl2N3O4S
Molar mass	446.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C3CNCCN3c2cc(ccc2OC)S(=O)(=O)Nc(c1OC)cc(Cl)cc1Cl;
	InChI InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3; Key:ATKZKAYWARYLBW-UHFFFAOYSA-N;
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SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT₆ receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT₆ antagonists show nootropic effects in animal studies, as well as antidepressant and anxiolytic effects which are comparable to and synergistic with drugs such as imipramine and diazepam, and have been proposed as potential novel treatments for cognitive disorders such as schizophrenia and Alzheimer's disease.