Zuranolone

Zuranolone
Clinical data
Pronunciation	/zʊˈrænəloʊn/; zuu-RAN-ə-lohn
Trade names	Zurzuvae
Other names	SAGE-217; S-812217; SGE-797; BIIB-125
AHFS/Drugs.com	Monograph
MedlinePlus	a623048
License data	US DailyMed: Zuranolone;
Pregnancy; category	Contraindicated;
Routes of; administration	By mouth
Drug class	Neurosteroid; GABAA receptor positive allosteric modulator
ATC code	N06AX31 (WHO) ;
Legal status
Legal status	CA: ℞-only; US: Schedule IV; EU: Rx-only;
Pharmacokinetic data
Protein binding	99.5%
Metabolism	CYP3A4
Elimination half-life	16–23 hours
Identifiers
	IUPAC name 1-(2-((3R,5R,8R,9R,10S,13S,14S,17S)-3-Hydroxy-3,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl)-1H-pyrazole-4-carbonitrile;
CAS Number	1632051-40-1;
PubChem CID	86294073;
DrugBank	DB15490;
ChemSpider	71117610;
UNII	7ZW49N180B;
KEGG	D11793;
ChEBI	CHEBI:228302;
ChEMBL	ChEMBL4105630;
CompTox Dashboard (EPA)	DTXSID601128500 ;
ECHA InfoCard	100.271.331
Chemical and physical data
Formula	C25H35N3O2
Molar mass	409.574 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(CN1N=CC(C#N)=C1)[C@H]2CC[C@@]3([H])[C@]4([H])CC[C@]5([H])C[C@](C)(O)CC[C@]5([H])[C@@]4([H])CC[C@@]32C;
	InChI InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1; Key:HARRKNSQXBRBGZ-GVKWWOCJSA-N;

Zuranolone, sold under the brand name Zurzuvae, is a medication used for the treatment of postpartum depression. It is taken by mouth. Zuranolone is a neuroactive steroid which enhances the activity of the neurotransmitter gamma-aminobutyric acid (GABA) and is thought to exert antidepressant effects by enhancing GABAergic inhibition.

The most common side effects include drowsiness, dizziness, diarrhea, fatigue, nasopharyngitis, and urinary tract infection.

Zuranolone was approved for medical use in the United States for the treatment of postpartum depression in August 2023. It was developed by Sage Therapeutics and Biogen.