Rosterolone

Rosterolone
Clinical data
Other names	SH-434; 17α-Propylmesterolone; 17β-Hydroxy-1α-methyl-17α-propyl-5α-androstan-3-one
Routes of; administration	Topical
Identifiers
	IUPAC name (1S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-17-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one;
CAS Number	79243-67-7;
PubChem CID	71232;
ChemSpider	64367;
UNII	3L5C5C8ZNG;
ChEMBL	ChEMBL2107498;
CompTox Dashboard (EPA)	DTXSID801033022 ;
ECHA InfoCard	100.071.904
Chemical and physical data
Formula	C23H38O2
Molar mass	346.555 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC1(CCC2C1(CCC3C2CCC4C3(C(CC(=O)C4)C)C)C)O;
	InChI InChI=1S/C23H38O2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25H,5-14H2,1-4H3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1; Key:IMFNBOMNWHWKQD-MXENSADDSA-N;

Rosterolone (INNTooltip International Nonproprietary Name) (developmental code name SH-434), also known as 17α-propylmesterolone or 1α-methyl-17α-propyl-5α-androstan-17β-ol-3-one, is a steroidal antiandrogen which was first described in 1984 and was developed for topical administration but was never marketed. It has shown some efficacy in the treatment of acne, and lacks systemic effects with either topical or systemic administration. Rosterolone is a derivative of mesterolone, which, in contrast, is an androgen and anabolic steroid.