Colossal Biosciences dire wolf project

The Colossal Biosciences dire wolf project is a project by Colossal Biosciences with the goal of replicating the phenotype of the extinct dire wolf (Aenocyon dirus) by genetic engineering. As of 2025, they had produced three genetically modified gray wolves (Canis lupus) that survived beyond infancy, named Romulus, Remus, and Khaleesi.

The project has received criticism from independent experts for the animals being referred to as dire wolves, as Romulus, Remus, and Khaleesi cannot be equated to the original species.

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