Rigidity theory (physics)

In physics, rigidity theory, or topological constraint theory, is a tool for predicting properties of complex networks (such as glasses) based on their composition. It was introduced by James Charles Phillips and refined by Michael Thorpe.

This theory reduces complex molecular networks to nodes (atoms, molecules, proteins, etc.) constrained by rods (chemical constraints), thus filtering out microscopic details that ultimately don't affect macroscopic properties.

Rigidity theory applied to the molecular networks arising from phenotypical expression of certain diseases may provide insights regarding their structure and function.

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