Ribonuclease T

Not to be confused with ribonuclease T1 or ribonuclease T2.
Ribonuclease T
A ribonuclease T dimer in complex with DNA (orange), from PDB ID 3NH1.
Identifiers
Symbolrnt
PfamPF00929
InterProIPR013520
SMARTSM00479
Available protein structures:
PDB  IPR013520 PF00929 (ECOD; PDBsum)  
AlphaFold

Ribonuclease T (RNase T, exonuclease T, exo T) is a ribonuclease enzyme involved in the maturation of transfer RNA and ribosomal RNA in bacteria, as well as in DNA repair pathways. It is a member of the DnaQ family of exonucleases and non-processively acts on the 3' end of single-stranded nucleic acids. RNase T is capable of cleaving both DNA and RNA, with extreme sequence specificity discriminating against cytosine at the 3' end of the substrate.

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