Replication terminator protein
| Replication terminator protein | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RTP | ||||||
| Pfam | PF02334 | ||||||
| InterPro | IPR003432 | ||||||
| SCOP2 | 1bm9 / SCOPe / SUPFAM | ||||||
| |||||||
The replication terminator protein (RTP) is a DNA-binding protein that helps terminate DNA replication in Bacillus. It has a winged-helix structure and forms a homodimer via hydrogen bonds. The dimer is symmetric when it is not bound to DNA, but becomes asymmetrical when it is bound. Its termination activity is polar: it stops the replication fork from continuing in one direction, but a fork going the other direction is allowed to proceed.