Renanolone

Renanolone
Clinical data
ATC code	none;
Identifiers
	IUPAC name 3α-hydroxy-5β-pregnane-11,20-dione;
CAS Number	565-99-1;
PubChem CID	68930;
ChemSpider	62156;
UNII	D8Z6E4IR2J;
CompTox Dashboard (EPA)	DTXSID101024028 ;
Chemical and physical data
Formula	C21H32O3
Molar mass	332.484 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C;
	InChI InChI=1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14-,15+,16-,17+,19-,20+,21-/m1/s1; Key:DUHUCHOQIDJXAT-CSXWOMMHSA-N;

Renanolone (INN; also known as 11-ketopregnanolone or 5β-pregnan-3α-ol-11,20-dione) is a synthetic neuroactive steroid which is described as a general anesthetic, but was never introduced for clinical use. Its isomers, alfaxolone and alfadolone, are also general anesthetics, and are known to act as positive allosteric modulators of the GABA_A receptor, a property which is likely the case for renanolone as well.