RU-28253

RU-28253
Clinical data
Other namesRU28253; 5-MeO-THPI
Drug classNon-selective serotonin receptor agonist
ATC code
  • None
Identifiers
  • 5-methoxy-3-(1,2,3,6-tetrahydropyridin-5-yl)-1H-indole
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)
  • COC1=CC2=C(C=C1)NC=C2C3=CCCNC3
  • InChI=1S/C14H16N2O/c1-17-11-4-5-14-12(7-11)13(9-16-14)10-3-2-6-15-8-10/h3-5,7,9,15-16H,2,6,8H2,1H3
  • Key:WBJMGSVSSCEGFV-UHFFFAOYSA-N

RU-28253, also known as 5-MeO-THPI, is a non-selective serotonin receptor agonist of the tryptamine, 5-methoxytryptamine, and tetrahydropyridinylindole families. It is a tetrahydropyridylindole and a conformationally constrained analogue of 5-MeO-DMT.

The drug shows high affinity for the serotonin 5-HT1A receptor (Ki = 5.7 nM) and lower affinity for the serotonin 5-HT2A receptor (Ki = 230 nM). Its affinities for these receptors were higher than those of dimethyltryptamine (DMT). RU-28253 is described as a potent agonist of the serotonin 5-HT1 and 5-HT2 receptors, including of the serotonin 5-HT1B receptor, and is also an agonist of the serotonin 5-HT4 receptor.

RU-28253 was first described in the scientific literature by 1983.

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