RS134-49

RS134-49
Clinical data
Other names4-Methyl-THPI; 4-Me-THPI
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist
Identifiers
  • 4-methyl-3-(1,2,3,6-tetrahydropyridin-5-yl)-1H-indole
CAS Number
PubChem CID
Chemical and physical data
FormulaC14H16N2
Molar mass212.296 g·mol−1
3D model (JSmol)
  • CC1=C2C(=CC=C1)NC=C2C3=CCCNC3
  • InChI=1S/C14H16N2/c1-10-4-2-6-13-14(10)12(9-16-13)11-5-3-7-15-8-11/h2,4-6,9,15-16H,3,7-8H2,1H3
  • Key:UIZDBLDTIJHWHC-UHFFFAOYSA-N

RS134-49, also known as 4-methyl-THPI, is a tetrahydropyridinylindole (THPI) derivative related to psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with a 5-HT2A Ki of 11.5nM and an EC50 of 22nM. It is a biased agonist selective for activation of the Gq coupled signalling pathway with weaker activation of the β-arrestin 2 coupled pathway, but shows a more balanced profile than related compounds such as (R)-69.

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