RAR-related orphan receptor gamma

RORC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B0W, 3KYT, 3L0J, 3L0L, 4NB6, 4NIE, 4QM0, 4S14, 4WLB, 4WPF, 4WQP, 4XT9, 4YMQ, 4ZJR, 4ZJW, 4ZOM, 5C4O, 5APK, 5APJ, 5APH, 5C4U, 5C4S, 5C4T, 4YPQ, 5AYG, 5IXK, 5IZ0, 5EJV, 5ETH
Identifiers
Aliases	RORC, NR1F3, RORG, RZR-GAMMA, RZRG, TOR, RAR-related orphan receptor gamma, IMD42, RAR related orphan receptor C
External IDs	OMIM: 602943; MGI: 104856; HomoloGene: 21051; GeneCards: RORC; OMA:RORC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,831,845 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	94,305,583 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; testicle; ; muscle of thigh; ; right lobe of liver; ; right uterine tube; ; Skeletal muscle tissue of rectus abdominis; ; parotid gland; ; body of pancreas; ; olfactory zone of nasal mucosa; ; vastus lateralis muscle;
	Top expressed in
	muscle of thigh; ; thymus; ; cortex of thymus; ; thin ascending limb of loop of Henle; ; pelvic ganglion; ; digastric muscle; ; skeletal muscle tissue; ; temporal muscle; ; extraocular muscle; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; ligand-activated transcription factor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; steroid hormone receptor activity; nuclear receptor activity; protein binding; oxysterol binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator binding;
Cellular component	nucleoplasm; nucleus; nuclear body;
Biological process	regulation of transcription, DNA-templated; rhythmic process; cellular response to sterol; negative regulation of thymocyte apoptotic process; circadian regulation of gene expression; regulation of fat cell differentiation; transcription, DNA-templated; regulation of steroid metabolic process; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of glucose metabolic process; circadian rhythm; xenobiotic metabolic process; positive regulation of circadian rhythm; adipose tissue development; T-helper 17 cell differentiation; Peyer's patch development; transcription initiation from RNA polymerase II promoter; T-helper cell differentiation; lymph node development; steroid hormone mediated signaling pathway; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6097
	19885
	ENSG00000143365
	ENSMUSG00000028150
	P51449
	P51450
	NM_001001523; NM_005060
	NM_001293734; NM_011281
	NP_001001523; NP_005051
	NP_001280663; NP_035411
	Wikidata
View/Edit Human	View/Edit Mouse

RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of the nuclear receptor family of transcription factors. It is mainly expressed in immune cells (Th17 cells) and it also regulates circadian rhythms. It may be involved in the progression of certain types of cancer.