RNF4

RNF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EA6, 2XEU, 4PPE
Identifiers
Aliases	RNF4, SLX5, SNURF, RES4-26, ring finger protein 4
External IDs	OMIM: 602850; MGI: 1201691; HomoloGene: 37711; GeneCards: RNF4; OMA:RNF4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,625,320 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,512,973 bp
RNA expression pattern
	Top expressed in
	thymus; ; oocyte; ; middle temporal gyrus; ; epithelium of colon; ; tonsil; ; secondary oocyte; ; bone marrow cell; ; lymph node; ; beta cell; ; stromal cell of endometrium;
	Top expressed in
	seminiferous tubule; ; zygote; ; lactiferous gland; ; cumulus cell; ; Ileal epithelium; ; secondary oocyte; ; ankle joint; ; yolk sac; ; spermatid; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; ubiquitin protein ligase activity; DNA-binding transcription factor activity; transcription coactivator activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; androgen receptor binding; identical protein binding; nucleosome binding; transferase activity; transcription factor binding; SUMO polymer binding; zinc ion binding; nuclear receptor coactivator activity;
Cellular component	cytoplasm; PML body; nucleoplasm; nucleus;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; protein K63-linked ubiquitination; response to arsenic-containing substance; transcription, DNA-templated; positive regulation of transcription, DNA-templated; protein K11-linked ubiquitination; regulation of kinetochore assembly; protein K48-linked ubiquitination; protein K6-linked ubiquitination; protein ubiquitination; regulation of spindle assembly; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	6047
	19822
	ENSG00000063978
	ENSMUSG00000029110
	P78317
	Q9QZS2
	NM_002938; NM_001185009; NM_001185010
	NM_011278; NM_001304269; NM_001304270
	NP_001171938; NP_001171939; NP_002929
	NP_001291198; NP_001291199; NP_035408
	Wikidata
View/Edit Human	View/Edit Mouse

RING finger protein 4 (RNF4) / Small nuclear ring finger protein (SNURF) is a 190-amino acid protein that in humans is encoded by the RNF4 gene

The RNF4 gene contains 2 nuclear localization signals (NLS), 8 exons, and is approximately 47 kb in length, and weighs ~18 kDa (without isoforms or tags)

The protein encoded by this gene contains a RING finger domain and acts as a transcription factor. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. This allows TRPS1-regulated genes to be expressed more. Transcription repressor ZNF278/PATZ1 is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis.