6,7-dihydropteridine reductase
| 6,7-dihydropteridine reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Dihydropteridine reductase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.5.1.34 | ||||||||
| CAS no. | 9074-11-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
6,7-dihydropteridine reductase (EC 1.5.1.34, also dihydrobiopterin reductase) is an enzyme that catalyzes the chemical reaction
The substrates of this enzyme are dihydrobiopterin (specifically the isomer (6R)-L-erythro-6,7-dihydrobiopterin), reduced nicotinamide adenine dinucleotide (NADH), and two protons. Its products are tetrahydropteridine and oxidised NAD+. Nicotinamide adenine dinucleotide phosphate can be used as an alternative cofactor. The enzyme participates in folate biosynthesis. In the human genome, the enzyme is encoded by the QDPR gene.