QKI

QKI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JVH
Identifiers
Aliases	QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding
External IDs	OMIM: 609590; MGI: 97837; HomoloGene: 11059; GeneCards: QKI; OMA:QKI - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	163,578,592 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	10,538,783 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; dorsal motor nucleus of vagus nerve; ; corpus callosum; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; pars reticulata; ; subthalamic nucleus; ; superior vestibular nucleus; ; internal globus pallidus;
	Top expressed in
	Gonadal ridge; ; otic placode; ; saccule; ; sciatic nerve; ; left lung lobe; ; deep cerebellar nuclei; ; substantia nigra; ; cumulus cell; ; lateral geniculate nucleus; ; tail of embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein binding; nucleic acid binding; mRNA binding; RNA binding;
Cellular component	cytoplasm; nucleus; synapse;
Biological process	cell differentiation; mRNA transport; mRNA processing; vasculogenesis; multicellular organism development; axon ensheathment; muscle cell differentiation; positive regulation of gene expression; long-chain fatty acid biosynthetic process; RNA splicing; spermatid development; myelination; 3'-UTR-mediated mRNA destabilization; regulation of translation; transport;
	Sources:Amigo / QuickGO
Orthologs
	9444
	19317
	ENSG00000112531
	ENSMUSG00000062078
	Q96PU8
	Q9QYS9
	NM_001301085; NM_006775; NM_206853; NM_206854; NM_206855
	NM_001159516; NM_001159517; NM_021881
	NP_001288014; NP_006766; NP_996735; NP_996736; NP_996737
	NP_001152988; NP_001152989; NP_068681
	Wikidata
View/Edit Human	View/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA. They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1. Two more new members are KHDRBS3 and KHDRBS2.

The QKI gene is implicated as being important in schizophrenia, and QKI controls translation of many oligodendrocyte-related genes.