Pyknosis

Pyknosis, or karyopyknosis, is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. It is typically followed by karyorrhexis, the fragmentation of the nucleus.

The term derives from Ancient Greek πυκνός meaning "thick, closed or condensed". Pyknosis also occurs as part of normal cell maturation in certain blood cells.

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