Proxicromil

Proxicromil
Names
	Preferred IUPAC name 5-Hydroxy-4-oxo-10-propyl-6,7,8,9-tetrahydro-4H-naphtho[2,3-b]pyran-2-carboxylic acid
	Other names Proxicromilum
Identifiers
CAS Number	60400-92-2;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL42641;
ChemSpider	58941;
KEGG	D05645;
PubChem CID	65493;
UNII	8WWZ0E633P ;
CompTox Dashboard (EPA)	DTXSID10209163 ;
	InChI InChI=1S/C17H18O5/c1-2-5-11-9-6-3-4-7-10(9)15(19)14-12(18)8-13(17(20)21)22-16(11)14/h8,19H,2-7H2,1H3,(H,20,21) Key: VFFTVZUIDYJUQS-UHFFFAOYSA-N;
	SMILES CCCC1=C2C(=C(C3=C1CCCC3)O)C(=O)C=C(O2)C(=O)O;
Properties
Chemical formula	C17H18O5
Molar mass	302.326 g·mol−1
Melting point	219 °C (426 °F; 492 K)
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	May cause cancer
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H350
Precautionary statements	P301+P312+P330, P308+P313
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Proxicromil is a detergent-like, lipophilic oral medication developed in the late 1970s that was not admitted on the market because of its possible carcinogenic effects. It suppresses allergic reactions by binding to FcεRI receptor in mast cells, thereby inhibiting production of histamines. It is absorbed through the gastrointestinal tract, and has been proven hepatotoxic for dogs as a result of its accumulation in biliary canaliculi.