Prentiss County, Mississippi

County of Prentiss
Prentiss County Courthouse in Booneville
Location within the U.S. state of Mississippi
Coordinates: 34°37′N 88°31′W / 34.61°N 88.52°W / 34.61; -88.52
Country United States
State Mississippi
FoundedApril 15, 1870 (1870-04-15)
Named afterSeargent Smith Prentiss
SeatBooneville
Largest cityBooneville
Area
 • Total
418 sq mi (1,080 km2)
 • Land415 sq mi (1,070 km2)
 • Water3.2 sq mi (8.3 km2)  0.8%
Population
 (2020)
 • Total
25,008
 • Estimate 
(2024)
25,489
 • Density60.3/sq mi (23.3/km2)
Time zoneUTC−6 (Central)
 • Summer (DST)UTC−5 (CDT)
Congressional district1st
Websitewww.prentisscounty.org

Prentiss County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 25,008. Its county seat is Booneville. The county is named for Seargent Smith Prentiss, a noted speaker and US Congressman from Natchez.