Prefoldin

Prefoldin
This is the crystal structure of an archaeal prefoldin taken from the archaeon Methanobacterium thermoautotrophicum. The image was produced by Siegerts, R., Scheufler, C., Moarefi, I. using X-Ray diffraction. The heterohexameric protein complex contains two alpha subunits, and four beta subunits. (PDB: 1FXK​)
Identifiers
SymbolPrefoldin
InterProIPR009053
CATH1fxk
SCOP21fxk / SCOPe / SUPFAM
Available protein structures:
PDB  IPR009053  
AlphaFold

Prefoldin (GimC) is a superfamily of proteins used in protein folding complexes. It is classified as a heterohexameric molecular chaperone in both archaea and eukarya, including humans. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins. One of prefoldin's main uses in eukarya is the formation of molecules of actin for use in the eukaryotic cytoskeleton.

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